Anastrozole Research Chemical

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Anastrozole Research Chemical

Anastrozole is often marketed under the name arimidex when it is being used for
clinical research. This chemical is an aromatase-inhibiting drug which is often featured
in research regarding finding more effective treatments for breast cancer after surgery.
Anastrozole is frequently applied to post-menopausal female animals, as the presence
of hyperplasia increases the risk of breast cancer that occurs at estrogen receptor.

In a natural setting anastrozole is used by the body to inhibit estrogen synthesis, which
can help to reduce the risk of diseases such as breast cancer that respond to
increased estrogen levels. The synthesized version of this chemical is being further
developed so it could potentially offer a similar service.

The safety of applying this chemical to animal test subjects and potential side effects of
this application are currently being investigated to ensure that this method of
treatment is safe and effective before commercial use in humans will be approved.

Chemical Synthesis of Anastrozole

When synthesizing anastrozole, necleophilic substitution of two benzlic bromides using
a cyanide treatment.

* During this treatment potassium cyanide is applied under phase transfer
conditions that afford the dinitrile.


* Applying exhaustive methylation with sodium hydride and methyl iodide allows for
the replacement of an acidic side chain of hydrogen atoms by these methyl
groups.

Treating the peptide with bromine helps to encourage the presence of benzoyl
peroxide which in turn permits the formation of corresponding benzyl bromide
molecules. This reaction creates a 1, 2, 4 triazole setup within the molecule that
creates the base for the peptide. This final reaction al ows the complete synthesis of an
aromatase inhibitor that mimics the reaction of anastrozole in a natural setting.

The Actions of Anastrozole

Synthetic anastrozole is quite successful at mimicking the actions of the natural
chemical, and these reactions have been consistently confirmed in animal test subjects
during research.

* Anastrozole is typical y applied to animal test subjects via injection which allows
the chemical to reach estrogen receptor sites as required by the animal's body.

* As the chemical reaches these sites anastrozole wil reversibly bind with existing
aromatase enzymes using competitive inhibition.

Binding to aromatase enzymes will allow anastrozole to inhibit androgens from
converting to estrogen in these peripheral tissues outside of the CNS. A few CNS sites
within a variety of regions throughout the brain will respond to anastrozole, al owing

this chemical to increase its effects when applied to animal test subjects in larger
doses.

The patent on Arimidex was originally held by AstraZeneca. However, this patent
expired in June of 2010, which has resulted in several companies working to synthesize
a similar product for use in research settings. Given this increasing variation of
products that will now be available online it is important to carefully research the
chemical makeup of the chemical peptide you plan to buy.

An alternative synthesis of this chemical could alter the effects of your research. Some
vials of anastrozole are also intended for use in males or developing animals rather
than females, which should alter the potency of this application.