Free radical scavenging activity of Indian haldi (Curcuma longa L.) against carbon tetrachloride induced hepatic damage in Rats

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Journal of Applied Biotechnology, Vol. 5(1) PP: 76-81
ISSN: 0970-838X, June, 2010
C@ Academic press, 2010




Free radical scavenging activity of Indian haldi (Curcuma longa L.) against
carbon tetrachloride induced hepatic damage in Rats.

Hamid Bakshi1, Smitha Sam2, Kusha Bardhwaj 2, C.S Senthil Kumar 2, Tahir M Mal a2,
Amit K Datta 2

1Laboratory of Tumor Biology, Department of Biotechnology, Bhoj Col ege, Bhopal

2Jawaharlal Nehru Cancer Hospital and Research Center Bhopal
Correspondence: [email protected]

Abstract

The present study was conducted to elucidate the effect of extract of Curcuma longa (CL) on blood
and liver gluthione, Na+ K+ ATPase activity and TBARS against carbon tetrachloride induced
hepatic damage in rats have been studied. In addition antioxidant enzymes like superoxide
dismutase (SOD) catalase (CAT), Glutathione peroxidase (GPX), Glutathione transferase (GST)
and Glutathione reductase (GSH-R) were also studied. It was interesting to observe that the
ethanolic extract of Curcuma longa leaves has reversal effects on the above mentioned
parameters in carbon tetrachloride hepatotoxicity. Based on these findings, we suggest that the
liver protective and antioxidant effect of CL possibly involves mechanism related to free radical
scavenging effects.

Key words: Free radical, Curcuma longa, TBARS, GST, Hepatotoxicity
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