What Is The Best Psoriasis Treatment?

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What Is The Best Psoriasis Treatment?
The treatment of psoriasis is changing quickly as new treatments emerge in the
management of this disease. The latest treatment to hit the world of psoriasis is that of
Biologic drugs, also called "biologics," are a fairly new class of treatment options for
psoriasis and psoriatic arthritis. They are given by injection or intravenous (IV) infusion.
Biologics are protein-derived drugs created in a laboratory from extraction out of living cells
such as bacteria which have been engineered to make the protein.
The difference between biologics and regular immune system drugs is that the biologics
attack only specific aspects of the immune system and traditional systemic agents have an
impact on the entire immune system. Biologics can block the action of proteins in the
immune system or can block the action of T cells in the immune system. Some of the
proteins blocked by the biologics include tumor necrosis factor-alpha (TNF-alpha) or some
of the interleukins in the immune system. These are cells and proteins which play a large
role in how people get psoriatic arthritis and psoriasis.
One T-cell blocker is called Amevive (Alefacept) which blocks the activation of T cells, which
are white cells, found in great numbers in the skin of psoriasis. T cells mistake the skin for a
foreign invader and there is a series of events that happen to inflame the skin and cause
psoriasis. Amevive is delivered by injection and works within several weeks.
Enbrel, Humira, Remicade and Simponi are all medications that block TNF-alpha. TNF-alpha
acts as an immune system mediator (a cytokine) that controls and promotes inflammation.
In psoriasis, it has been found that TNF-alpha is produced in excess in the skin and joints of
psoriasis sufferers and causes the rapid proliferation of skin tissue as well as damage to the
tissue around the joints. If you block the TNF-alpha signal, it blocks the inflammatory cycle
involved in psoriasis and related diseases.
Medications that block interleukin 12 and interleukin 23 include Stelara (ustekinumab). This
drug is selective against the cytokines known as interleukin 12 and interleukin 23. They are
found in large numbers in the skin of psoriasis sufferers. They are believed to be what
activates the T cells in the body.
Biologics are all given by intramuscular injection or by intravenous use. Amevive is given by
means of an intramuscular injection and Enbrel, Simponi and Humira are injected into the
legs, abdomen or arms. You can get them at home and can be given by the individual or a
family member. Stelara is a subcutaneous injection given at the doctor's office. Remicade is
given by IV at a hospital or doctor's office. They are used in patients with an intact immune
system who have moderate to severe cases of psoriatic arthritis or plaque psoriasis. They
take several weeks to work and not everyone can find relief from them. In addition, you
cannot take the injections if you have an active, ongoing infection.
Doctors generally screen for the basic infections before giving these drugs, including
screening for tuberculosis. The risks of taking these biologic agents include giving the

individual an infection. It is unknown whether or not the biologics affect a fetus so they
cannot be given to pregnant mothers.
If you follow your psoriasis treatment plan and have a healthy lifestyle, then everything
can only go better. Psoriasis lesions are just a temporary condition that goes away if You
live Your life and dont worry.
Stressing is the only thing you can do wrong. Psoriatic, I have realized that in the end it is
as easy or as hard as you take it.
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